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The Molecular Mechanism of Substrate Engagement and Immunosuppressant Inhibition of Calcineurin
Ser/thr phosphatases dephosphorylate their targets with high specificity, yet the structural and sequence determinants of phosphosite recognition are poorly understood. Calcineurin (CN) is a conserved Ca(2+)/calmodulin-dependent ser/thr phosphatase and the target of immunosuppressants, FK506 and cyc...
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| Main Authors: | , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Public Library of Science
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3582496/ https://ncbi.nlm.nih.gov/pubmed/23468591 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001492 |
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