טוען...
A conserved docking surface on calcineurin mediates interaction with substrates and immunosuppressants
The phosphatase calcineurin, target of the immunosuppressants cyclosporin A and FK506, dephosphorylates NFAT transcription factors to promote immune activation and development of the vascular and nervous systems. NFAT interacts with calcineurin through distinct binding motifs: the PxIXIT and LxVP si...
שמור ב:
| Main Authors: | , , , , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2009
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2667333/ https://ncbi.nlm.nih.gov/pubmed/19285944 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.01.030 |
| תגים: |
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