A conserved docking surface on calcineurin mediates interaction with substrates and immunosuppressants

The phosphatase calcineurin, target of the immunosuppressants cyclosporin A and FK506, dephosphorylates NFAT transcription factors to promote immune activation and development of the vascular and nervous systems. NFAT interacts with calcineurin through distinct binding motifs: the PxIXIT and LxVP si...

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Main Authors: Rodríguez, Antonio, Roy, Jagoree, Martínez-Martínez, Sara, López-Maderuelo, Ma Dolores, Niño-Moreno, Perla, Ortí, Leticia, Pantoja, David, Pineda-Lucena, Antonio, Cyert, Martha S., Redondo, Juan Miguel
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667333/
https://ncbi.nlm.nih.gov/pubmed/19285944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.01.030
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