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A conserved docking surface on calcineurin mediates interaction with substrates and immunosuppressants
The phosphatase calcineurin, target of the immunosuppressants cyclosporin A and FK506, dephosphorylates NFAT transcription factors to promote immune activation and development of the vascular and nervous systems. NFAT interacts with calcineurin through distinct binding motifs: the PxIXIT and LxVP si...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2667333/ https://ncbi.nlm.nih.gov/pubmed/19285944 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.01.030 |
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