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Orthogonal array formation by human aquaporin-4: Examination of neuromyelitis optica-associated aquaporin-4 polymorphisms

Pathogenic autoantibodies target aquaporin-4 (AQP4) water channels in individuals with neuromyelitis optica (NMO). Recently, allelic mutations were reported at residue 19 of AQP4 in three cases of NMO, and it was suggested that polymorphisms may influence disease by altering AQP4 supramolecular asse...

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Hlavní autoři: Crane, Jonathan M., Rossi, Andrea, Gupta, Tripta, Bennett, Jeffrey L., Verkman, A.S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3582392/
https://ncbi.nlm.nih.gov/pubmed/21621278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2011.05.001
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