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Orthogonal array formation by human aquaporin-4: Examination of neuromyelitis optica-associated aquaporin-4 polymorphisms

Pathogenic autoantibodies target aquaporin-4 (AQP4) water channels in individuals with neuromyelitis optica (NMO). Recently, allelic mutations were reported at residue 19 of AQP4 in three cases of NMO, and it was suggested that polymorphisms may influence disease by altering AQP4 supramolecular asse...

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Detalhes bibliográficos
Main Authors: Crane, Jonathan M., Rossi, Andrea, Gupta, Tripta, Bennett, Jeffrey L., Verkman, A.S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3582392/
https://ncbi.nlm.nih.gov/pubmed/21621278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2011.05.001
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