Hypoxia-responsive miRNAs target argonaute 1 to promote angiogenesis

Despite a general repression of translation under hypoxia, cells selectively upregulate a set of hypoxia-inducible genes. Results from deep sequencing revealed that Let-7 and miR-103/107 are hypoxia-responsive microRNAs (HRMs) that are strongly induced in vascular endothelial cells. In silico bioinf...

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Bibliographische Detailangaben
Hauptverfasser: Chen, Zhen, Lai, Tsung-Ching, Jan, Yi-Hua, Lin, Feng-Mao, Wang, Wei-Chi, Xiao, Han, Wang, Yun-Ting, Sun, Wei, Cui, Xiaopei, Li, Ying-Shiuan, Fang, Tzan, Zhao, Hongwei, Padmanabhan, Chellappan, Sun, Ruobai, Wang, Danny Ling, Jin, Hailing, Chau, Gar-Yang, Huang, Hsien-Da, Hsiao, Michael, Shyy, John Y-J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3582133/
https://ncbi.nlm.nih.gov/pubmed/23426184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI65344
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