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Argonaute-miRNA Complexes Silence Target mRNAs in the Nucleus of Mammalian Stem Cells
In mammals, gene silencing by the RNA-induced silencing complex (RISC) is a well-understood cytoplasmic posttranscriptional gene regulatory mechanism. Here, we show that embryonic stem cells (ESCs) contain high levels of nuclear AGO proteins and that in ESCs nuclear AGO protein activity allows for t...
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| Publicado en: | Mol Cell |
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| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6690358/ https://ncbi.nlm.nih.gov/pubmed/30146314 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.07.020 |
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