Argonaute-miRNA Complexes Silence Target mRNAs in the Nucleus of Mammalian Stem Cells

In mammals, gene silencing by the RNA-induced silencing complex (RISC) is a well-understood cytoplasmic posttranscriptional gene regulatory mechanism. Here, we show that embryonic stem cells (ESCs) contain high levels of nuclear AGO proteins and that in ESCs nuclear AGO protein activity allows for t...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:Mol Cell
Päätekijät: Sarshad, Aishe A., Juan, Aster H., Muler, Ana Iris Correa, Anastasakis, Dimitrios G., Wang, Xiantao, Genzor, Pavol, Feng, Xuesong, Tsai, Pei-Fang, Sun, Hong-Wei, Haase, Astrid D., Sartorelli, Vittorio, Hafner, Markus
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2018
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690358/
https://ncbi.nlm.nih.gov/pubmed/30146314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.07.020
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