Transforming mutations of RAC guanosine triphosphatases in human cancers

Members of the RAS superfamily of small guanosine triphosphatases (GTPases) transition between GDP-bound, inactive and GTP-bound, active states and thereby function as binary switches in the regulation of various cellular activities. Whereas HRAS, NRAS, and KRAS frequently acquire transforming misse...

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Autors principals: Kawazu, Masahito, Ueno, Toshihide, Kontani, Kenji, Ogita, Yoshitaka, Ando, Mizuo, Fukumura, Kazutaka, Yamato, Azusa, Soda, Manabu, Takeuchi, Kengo, Miki, Yoshio, Yamaguchi, Hiroyuki, Yasuda, Takahiko, Naoe, Tomoki, Yamashita, Yoshihiro, Katada, Toshiaki, Choi, Young Lim, Mano, Hiroyuki
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2013
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581941/
https://ncbi.nlm.nih.gov/pubmed/23382236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1216141110
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