Transforming somatic mutations of mammalian target of rapamycin kinase in human cancer

Mammalian target of rapamycin (mTOR) is a serine–threonine kinase that acts downstream of the phosphatidylinositol 3‐kinase signaling pathway and regulates a wide range of cellular functions including transcription, translation, proliferation, apoptosis, and autophagy. Whereas genetic alterations th...

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Bibliografiske detaljer
Udgivet i:Cancer Sci
Main Authors: Yamaguchi, Hiroyuki, Kawazu, Masahito, Yasuda, Takahiko, Soda, Manabu, Ueno, Toshihide, Kojima, Shinya, Yashiro, Masakazu, Yoshino, Ichiro, Ishikawa, Yuichi, Sai, Eirin, Mano, Hiroyuki
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2015
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4714661/
https://ncbi.nlm.nih.gov/pubmed/26432419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12828
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