Coexistence of ribbon and helical fibrils originating from hIAPP(20–29) revealed by quantitative nanomechanical atomic force microscopy

Uncontrolled misfolding of proteins leading to the formation of amyloid deposits is associated with more than 40 types of diseases, such as neurodegenerative diseases and type-2 diabetes. These irreversible amyloid fibrils typically assemble in distinct stages. Transitions among the various intermed...

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Bibliographic Details
Main Authors: Zhang, Shuai, Andreasen, Maria, Nielsen, Jakob T., Liu, Lei, Nielsen, Erik H., Song, Jie, Ji, Gang, Sun, Fei, Skrydstrup, Troels, Besenbacher, Flemming, Nielsen, Niels C., Otzen, Daniel E., Dong, Mingdong
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2013
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581879/
https://ncbi.nlm.nih.gov/pubmed/23388629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1209955110
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