The N Termini of a-Subunit Isoforms Are Involved in Signaling between Vacuolar H(+)-ATPase (V-ATPase) and Cytohesin-2

Previously, we reported an acidification-dependent interaction of the endosomal vacuolar H(+)-ATPase (V-ATPase) with cytohesin-2, a GDP/GTP exchange factor (GEF), suggesting that it functions as a pH-sensing receptor. Here, we have studied the molecular mechanism of signaling between the V-ATPase, c...

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Detalhes bibliográficos
Main Authors: Hosokawa, Hiroyuki, Dip, Phat Vinh, Merkulova, Maria, Bakulina, Anastasia, Zhuang, Zhenjie, Khatri, Ashok, Jian, Xiaoying, Keating, Shawn M., Bueler, Stephanie A., Rubinstein, John L., Randazzo, Paul A., Ausiello, Dennis A., Grüber, Gerhard, Marshansky, Vladimir
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Bioenergetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581410/
https://ncbi.nlm.nih.gov/pubmed/23288846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.409169
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