The N Termini of a-Subunit Isoforms Are Involved in Signaling between Vacuolar H(+)-ATPase (V-ATPase) and Cytohesin-2

Previously, we reported an acidification-dependent interaction of the endosomal vacuolar H(+)-ATPase (V-ATPase) with cytohesin-2, a GDP/GTP exchange factor (GEF), suggesting that it functions as a pH-sensing receptor. Here, we have studied the molecular mechanism of signaling between the V-ATPase, c...

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Bibliografiska uppgifter
Huvudupphovsmän: Hosokawa, Hiroyuki, Dip, Phat Vinh, Merkulova, Maria, Bakulina, Anastasia, Zhuang, Zhenjie, Khatri, Ashok, Jian, Xiaoying, Keating, Shawn M., Bueler, Stephanie A., Rubinstein, John L., Randazzo, Paul A., Ausiello, Dennis A., Grüber, Gerhard, Marshansky, Vladimir
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2013
Ämnen:
Bioenergetics
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581410/
https://ncbi.nlm.nih.gov/pubmed/23288846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.409169
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