SUMOylation of Pancreatic Glucokinase Regulates Its Cellular Stability and Activity

Glucokinase is the predominant hexokinase expressed in hepatocytes and pancreatic β-cells, with a pivotal role in regulating glucose-stimulated insulin secretion, illustrated by glucokinase gene mutations causing monogenic diabetes and congenital hyperinsulinemic hypoglycemia. A complex tissue-speci...

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Detalhes bibliográficos
Main Authors: Aukrust, Ingvild, Bjørkhaug, Lise, Negahdar, Maria, Molnes, Janne, Johansson, Bente B., Müller, Yvonne, Haas, Wilhelm, Gygi, Steven P., Søvik, Oddmund, Flatmark, Torgeir, Kulkarni, Rohit N., Njølstad, Pål R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581398/
https://ncbi.nlm.nih.gov/pubmed/23297408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.393769
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