GCK-MODY diabetes associated with protein misfolding, cellular self-association and degradation

GCK-MODY, dominantly inherited mild fasting hyperglycemia, has been associated with >600 different mutations in the glucokinase (GK)-encoding gene (GCK). When expressed as recombinant pancreatic proteins, some mutations result in enzymes with normal/near-normal catalytic properties. The molecular...

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Main Authors: Negahdar, Maria, Aukrust, Ingvild, Johansson, Bente B., Molnes, Janne, Molven, Anders, Matschinsky, Franz M., Søvik, Oddmund, Kulkarni, Rohit N., Flatmark, Torgeir, Njølstad, Pål Rasmus, Bjørkhaug, Lise
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3444650/
https://ncbi.nlm.nih.gov/pubmed/22820548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2012.07.005
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