Binding of ATP at the active site of human pancreatic glucokinase – nucleotide-induced conformational changes with possible implications for its kinetic cooperativity

Glucokinase (GK) is the central player in glucose-stimulated insulin release from pancreatic β-cells, and catalytic activation by α-d-glucose binding has a key regulatory function. Whereas the mechanism of this activation is well understood, on the basis of crystal structures of human GK, there are...

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Detalhes bibliográficos
Main Authors: Molnes, Janne, Teigen, Knut, Aukrust, Ingvild, Bjørkhaug, Lise, Søvik, Oddmund, Flatmark, Torgeir, Njølstad, Pål Rasmus
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2011
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3531626/
https://ncbi.nlm.nih.gov/pubmed/21569204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2011.08160.x
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