Haploinsufficiency of the Ammonia Transporter Rhcg Predisposes to Chronic Acidosis: Rhcg IS CRITICAL FOR APICAL AND BASOLATERAL AMMONIA TRANSPORT IN THE MOUSE COLLECTING DUCT

Ammonia secretion by the collecting duct (CD) is critical for acid-base homeostasis and, when defective, causes distal renal tubular acidosis (dRTA). The Rhesus protein RhCG mediates NH(3) transport as evident from cell-free and cellular models as well as from Rhcg-null mice. Here, we investigated i...

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Bibliographic Details
Main Authors: Bourgeois, Soline, Bounoure, Lisa, Christensen, Erik I., Ramakrishnan, Suresh K., Houillier, Pascal, Devuyst, Olivier, Wagner, Carsten A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Membrane Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581388/
https://ncbi.nlm.nih.gov/pubmed/23281477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.441782
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