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Selective Serotonin Reuptake Inhibitors (SSRIs) Inhibit Insulin Secretion and Action in Pancreatic β Cells

Selective serotonin reuptake inhibitors (SSRIs) are antidepressants used for the treatment of mood and anxiety disorders. Here, we demonstrate that incubation (2 h) of murine islets or Min6 β cell line with the SSRIs paroxetine, fluoxetine, or sertraline inhibited insulin-induced Tyr phosphorylation...

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Hlavní autoři: Isaac, Roi, Boura-Halfon, Sigalit, Gurevitch, Diana, Shainskaya, Alla, Levkovitz, Yechiel, Zick, Yehiel
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581374/
https://ncbi.nlm.nih.gov/pubmed/23275337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.408641
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