Two discreet subsets of CD8 T cells modulate PLP(91-110) induced experimental autoimmune encephalomyelitis in HLA-DR3 transgenic mice

Previously we showed that transgenic mice expressing human HLA-DR3 gene are susceptible to PLP(91-110) induced experimental autoimmune encephalomyelitis (EAE) and can serve as an animal model of multiple sclerosis (MS). HLA-DR3 mice with EAE showed increased number of CD8 T cells indicating their im...

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Hauptverfasser: Mangalam, Ashutosh K., Luckey, David, Giri, Shailendra, Smart, Michele, Pease, Larry R., Rodriguez, Moses, David, Chella S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581307/
https://ncbi.nlm.nih.gov/pubmed/22459490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2012.02.004
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