Absence of IFNγ Increases Brain Pathology in EAE-susceptible DRB1*0301.DQ8 HLA Transgenic Mice Through Secretion of Pro-inflammatory Cytokine IL-17 and Induction of Pathogenic Monocytes/Microglia into the CNS

Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system (CNS) of presumed autoimmune origin. Of all the genetic factors linked with MS, MHC class-II molecules have the strongest association. Generation of HLA class-II transgenic mice has helped to elucidate th...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Mangalam, Ashutosh, Luo, Ningling, Luckey, David, Papke, Louisa, Hubbard, Alyssa, Wussow, Arika, Smart, Michele, Giri, Shailendra, Rodriguez, Moses, David, Chella
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4233133/
https://ncbi.nlm.nih.gov/pubmed/25339670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1302008
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