Fully recombinant IgG2a Fc multimers (stradomers) effectively treat collagen-induced arthritis and prevent idiopathic thrombocytopenic purpura in mice

INTRODUCTION: Soluble immune aggregates bearing intact Fc fragments are effective treatment for a variety of autoimmune disorders in mice. The better to understand the mechanisms by which Fc-bearing immune complexes suppress autoimmunity, and to develop a platform for clinical translation, we create...

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Main Authors: Jain, Ajay, Olsen, Henrik S, Vyzasatya, Ravi, Burch, Erin, Sakoda, Yukimi, Mérigeon, Emmanuel Y, Cai, Ling, Lu, Changwan, Tan, Ming, Tamada, Koji, Schulze, Dan, Block, David S, Strome, Scott E
格式: Artigo
語言:Inglês
出版: BioMed Central 2012
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3580588/
https://ncbi.nlm.nih.gov/pubmed/22906120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar4024
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