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Differential effects of Th1 versus Th2 cytokines in combination with hypoxia on HIFs and angiogenesis in RA

INTRODUCTION: Hypoxia and T-helper cell 1 (Th1) cytokine-driven inflammation are key features of rheumatoid arthritis (RA) and contribute to disease pathogenesis by promoting angiogenesis. The objective of our study was to characterise the angiogenic gene signature of RA fibroblast-like synoviocytes...

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Detalhes bibliográficos
Main Authors: Larsen, Helene, Muz, Barbara, Khong, Tak L, Feldmann, Marc, Paleolog, Ewa M
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3580575/
https://ncbi.nlm.nih.gov/pubmed/22866899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3934
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