Enhanced interleukin-1β production of PBMCs from patients with gout after stimulation with Toll-like receptor-2 ligands and urate crystals

INTRODUCTION: Monosodium urate monohydrate (MSU) crystals synergize with various toll-like receptor (TLR) ligands to induce cytokine production via activation of the NOD-like receptor (NLR) family, pyrin domain-containing 3 (NLPR3) inflammasome. This has been demonstrated in vitro using human cell l...

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Autors principals: Mylona, Eleni E, Mouktaroudi, Maria, Crisan, Tania O, Makri, Stamatoula, Pistiki, Aikaterini, Georgitsi, Marianna, Savva, Athina, Netea, Mihai G, van der Meer, Jos WM, Giamarellos-Bourboulis, Evangelos J, Joosten, Leo AB
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3580550/
https://ncbi.nlm.nih.gov/pubmed/22762240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3898
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