Inhibition of caspase-1 activation in gram-negative sepsis and experimental endotoxemia

INTRODUCTION: Down-regulation of ex-vivo cytokine production is a specific feature in patients with sepsis. Cytokine downregulation was studied focusing on caspase-1 activation and conversion of pro-interleukin-1β into interleukin-1β (IL-1β). METHODS: Peripheral blood mononuclear cells were isolated...

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Hlavní autoři: Giamarellos-Bourboulis, Evangelos J, van de Veerdonk, Frank L, Mouktaroudi, Maria, Raftogiannis, Maria, Antonopoulou, Anastasia, Joosten, Leo AB, Pickkers, Peter, Savva, Athina, Georgitsi, Marianna, van der Meer, Jos WM, Netea, Mihai G
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2011
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3222063/
https://ncbi.nlm.nih.gov/pubmed/21244670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/cc9974
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