DNA template strand sequencing of single-cells maps genomic rearrangements at high resolution

DNA rearrangements such as sister chromatid exchanges (SCEs) are sensitive indicators of genomic stress and instability, but they are typically masked by single-cell sequencing techniques. We developed Strand-seq to independently sequence parental DNA template strands from single cells, making it po...

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Autori principali: Falconer, Ester, Hills, Mark, Naumann, Ulrike, Poon, Steven S S, Chavez, Elizabeth A, Sanders, Ashley D, Zhao, Yongjun, Hirst, Martin, Lansdorp, Peter M
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3580294/
https://ncbi.nlm.nih.gov/pubmed/23042453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.2206
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