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DNA template strand sequencing of single-cells maps genomic rearrangements at high resolution
DNA rearrangements such as sister chromatid exchanges (SCEs) are sensitive indicators of genomic stress and instability, but they are typically masked by single-cell sequencing techniques. We developed Strand-seq to independently sequence parental DNA template strands from single cells, making it po...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3580294/ https://ncbi.nlm.nih.gov/pubmed/23042453 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.2206 |
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