Generation of transgenic mice with antithetical KEL1 and KEL2 human blood group antigens on red blood cells

BACKGROUND: KEL1, also known as “K,” is one of the most immunogenic red blood cell (RBC) antigens. KEL2, also known as “k,” differs from KEL1 by a single amino acid. Anti-Kell system antibodies can lead to significant adverse clinical outcomes in humans, including hemolytic complications in alloimmu...

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Bibliographic Details
Main Authors: Smith, Nicole H., Henry, Kate L., Cadwell, Chantel M., Bennett, Ashley, Hendrickson, Jeanne E., Frame, Tom, Zimring, James C.
Format: Artigo
Language:Inglês
Published: 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3580151/
https://ncbi.nlm.nih.gov/pubmed/22494154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1537-2995.2012.03641.x
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