The spleen plays a central role in primary humoral alloimmunization to transfused mHEL red blood cells

BACKGROUND: Several differences exist between antigens on transfused red blood cells (RBCs) and other immunogens, including anatomical compartmentalization. Whereas antigens from microbial pathogens and solid organ transplants drain into local lymph nodes, circulating RBCs remain segregated in the p...

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Autori principali: Hendrickson, Jeanne E., Saakadze, Natia, Cadwell, Chantel M., Upton, Jason W., Mocarski, Edward S., Hillyer, Christopher D., Zimring, James C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3568957/
https://ncbi.nlm.nih.gov/pubmed/19413728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1537-2995.2009.02200.x
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