An Intracellular Threonine of Amyloid-β Precursor Protein Mediates Synaptic Plasticity Deficits and Memory Loss

Mutations in Amyloid-ß Precursor Protein (APP) and BRI2/ITM2b genes cause Familial Alzheimer and Danish Dementias (FAD/FDD), respectively. APP processing by BACE1, which is inhibited by BRI2, yields sAPPß and ß-CTF. ß-CTF is cleaved by gamma-secretase to produce Aß. A knock-in mouse model of FDD, ca...

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Main Authors: Lombino, Franco, Biundo, Fabrizio, Tamayev, Robert, Arancio, Ottavio, D’Adamio, Luciano
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3579798/
https://ncbi.nlm.nih.gov/pubmed/23451158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0057120
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