Lunatic Fringe Enhances Competition for Delta-Like Notch Ligands but Does Not Overcome Defective Pre-TCR Signaling during Thymocyte β-Selection In Vivo

Notch1 activation by Delta-like (DL) Notch ligands is essential to induce T cell commitment and to suppress B cell development from thymus-seeding progenitors. Thymus-seeding progenitor competition for DL4 is critically regulated by Lunatic Fringe (Lfng), which glycosylates epidermal growth factor r...

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Bibliographic Details
Main Authors: Visan, Ioana, Yuan, Julie S., Liu, Ying, Stanley, Pamela, Guidos, Cynthia J.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3579566/
https://ncbi.nlm.nih.gov/pubmed/20844195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1002008
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