Lunatic Fringe-mediated Notch signaling is required for lung alveogenesis

Distal lung development occurs through coordinated induction of myofibroblasts, epithelial cells, and capillaries. Lunatic Fringe (Lfng) is a β(1–3) N-acetylglucosamine transferase that modifies Notch receptors to facilitate their activation by Delta-like (Dll1/4) ligands. Lfng is expressed in the d...

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Autors principals: Xu, Keli, Nieuwenhuis, Erica, Cohen, Brenda L., Wang, Wei, Canty, Angelo J., Danska, Jayne S., Coultas, Leigh, Rossant, Janet, Wu, Megan Y. J., Piscione, Tino D., Nagy, Andras, Gossler, Achim, Hicks, Geoff G., Hui, Chi-Chung, Henkelman, R. Mark, Yu, Lisa X., Sled, John G., Gridley, Thomas, Egan, Sean E.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2010
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806195/
https://ncbi.nlm.nih.gov/pubmed/19897741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.90550.2008
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