Lunatic Fringe Deficiency Cooperates with the Met/Caveolin Gene Amplicon to Induce Basal-like Breast Cancer

Basal-like breast cancers (BLBC) express a luminal progenitor gene signature. Notch receptor signaling promotes luminal cell fate specification in the mammary gland, while suppressing stem cell self-renewal. Here we show that deletion of Lfng, a sugar transferase that prevents Notch activation by Ja...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Xu, Keli, Usary, Jerry, Kousis, Philaretos C., Prat, Aleix, Wang, Dong-Yu, Adams, Jessica R., Wang, Wei, Loch, Amanda J., Deng, Tao, Zhao, Wei, Cardiff, Robert Darrell, Yoon, Keejung, Gaiano, Nicholas, Ling, Vicki, Beyene, Joseph, Zacksenhaus, Eldad, Gridley, Tom, Leong, Wey L., Guidos, Cynthia J., Perou, Charles M., Egan, Sean E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2012
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3603366/
https://ncbi.nlm.nih.gov/pubmed/22624713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2012.03.041
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