Anti-IL-5 attenuates activation and surface density of β(2)-integrins on circulating eosinophils after segmental antigen challenge

BACKGROUND: IL-5 activates α(M)β(2) integrin on blood eosinophils in vitro. Eosinophils in bronchoalveolar lavage (BAL) following segmental antigen challenge have activated β(2)-integrins. OBJECTIVE: To identify roles for IL-5 in regulating human eosinophil integrins in vivo. METHODS: Blood and BAL...

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Main Authors: Johansson, Mats W., Gunderson, Kristin A., Kelly, Elizabeth A. B., Denlinger, Loren C., Jarjour, Nizar N., Mosher, Deane F.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3579563/
https://ncbi.nlm.nih.gov/pubmed/23414537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2222.2012.04065.x
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