Mepolizumab Attenuates Airway Eosinophil Numbers, but Not Their Functional Phenotype, in Asthma

Rationale: Mepolizumab, an IL-5–blocking antibody, reduces exacerbations in patients with severe eosinophilic asthma. Mepolizumab arrests eosinophil maturation; however, the functional phenotype of eosinophils that persist in the blood and airway after administration of IL-5 neutralizing antibodies...

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Bibliografiske detaljer
Udgivet i:Am J Respir Crit Care Med
Main Authors: Kelly, Elizabeth A., Esnault, Stephane, Liu, Lin Ying, Evans, Michael D., Johansson, Mats W., Mathur, Sameer, Mosher, Deane F., Denlinger, Loren C., Jarjour, Nizar N.
Format: Artigo
Sprog:Inglês
Udgivet: American Thoracic Society 2017
Fag:
Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5736971/
https://ncbi.nlm.nih.gov/pubmed/28862877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201611-2234OC
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