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An inducible translocation strategy to rapidly activate and inhibit small GTPase signaling pathways

We made substantial advances in the implementation of a rapamycin-triggered heterodimerization strategy. Using molecular engineering of different targeting and enzymatic fusion constructs and a new rapamycin analog, Rho GTPases were directly activated or inactivated on a timescale of seconds, which...

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Bibliografiske detaljer
Main Authors: Inoue, Takanari, Heo, Won Do, Grimley, Joshua S, Wandless, Thomas J, Meyer, Tobias
Format: Artigo
Sprog:Inglês
Udgivet: 2005
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3579513/
https://ncbi.nlm.nih.gov/pubmed/15908919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth763
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