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An inducible translocation strategy to rapidly activate and inhibit small GTPase signaling pathways
We made substantial advances in the implementation of a rapamycin-triggered heterodimerization strategy. Using molecular engineering of different targeting and enzymatic fusion constructs and a new rapamycin analog, Rho GTPases were directly activated or inactivated on a timescale of seconds, which...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3579513/ https://ncbi.nlm.nih.gov/pubmed/15908919 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth763 |
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