Chemoenzymatic Asymmetric Synthesis of Pregabalin Precursors via Asymmetric Bioreduction of β-Cyanoacrylate Esters Using Ene-Reductases

[Image: see text] The asymmetric bioreduction of a library of β-cyanoacrylate esters using ene-reductases was studied with the aim to provide a biocatalytic route to precursors for GABA analogues, such as pregabalin. The stereochemical outcome could be controlled by substrate-engineering through siz...

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Main Authors: Winkler, Christoph K., Clay, Dorina, Davies, Simon, O’Neill, Pat, McDaid, Paul, Debarge, Sebastien, Steflik, Jeremy, Karmilowicz, Mike, Wong, John W., Faber, Kurt
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2013
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3579311/
https://ncbi.nlm.nih.gov/pubmed/23316696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo302484p
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