Sorafenib and its derivative SC-49 sensitize hepatocellular carcinoma cells to CS-1008, a humanized anti-TNFRSF10B (DR5) antibody

BACKGROUND AND PURPOSE: Previously, we have shown that sorafenib sensitizes hepatocellular carcinoma (HCC) to apoptosis induced by TNF-related apoptosis-inducing ligand (TNFSF10; TRAIL). Here, we report that sorafenib and SC-49 sensitize HCC cells to CS-1008, a novel anti-human death receptor 5 (TNF...

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Detalhes bibliográficos
Main Authors: Chen, Kuen-Feng, Chen, Hui-Ling, Shiau, Chung-Wai, Liu, Chun-Yu, Chu, Pei-Yi, Tai, Wei-Tien, Ichikawa, Kimihisa, Chen, Pei-Jer, Cheng, Ann-Lii
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3579286/
https://ncbi.nlm.nih.gov/pubmed/22978563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2012.02212.x
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