Insulin at normal physiological levels does not prolong QT(c) interval in thorough QT studies performed in healthy volunteers

AIMS: Food is known to shorten the QT(c) (QT(c)I and QT(c)F) interval and has been proposed as a non-pharmacological method of confirming assay sensitivity in thorough QT (TQT) studies and early phase studies in medicines research. Intake of food leads to a rise in insulin levels together with the r...

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Bibliografiske detaljer
Main Authors: Taubel, Jorg, Lorch, Ulrike, Ferber, Georg, Singh, Jatinder, Batchvarov, Velislav N, Savelieva, Irina, Camm, A John
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 2013
Fag:
Clinical Trials
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3579254/
https://ncbi.nlm.nih.gov/pubmed/22775199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2012.04376.x
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