ADAR2-editing activity inhibits glioblastoma growth through the modulation of the CDC14B/Skp2/p21/p27 axis

Grade IV astrocytoma or glioblastoma multiforme (GBM) is one of the most aggressive and lethal tumors affecting humans. ADAR2-mediated A-to-I RNA editing, an essential post-transcriptional modification event in brain, is impaired in GBMs and astrocytoma cell lines. However, the role of ADAR2 editing...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Galeano, F, Rossetti, C, Tomaselli, S, Cifaldi, L, Lezzerini, M, Pezzullo, M, Boldrini, R, Massimi, L, Di Rocco, C M, Locatelli, F, Gallo, A
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2013
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3579159/
https://ncbi.nlm.nih.gov/pubmed/22525274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.125
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