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IRAK-M mediates Toll-like receptor/IL-1R-induced NFκB activation and cytokine production
Toll-like receptors transduce their signals through the adaptor molecule MyD88 and members of the IL-1R-associated kinase family (IRAK-1, 2, M and 4). IRAK-1 and IRAK-2, known to form Myddosomes with MyD88–IRAK-4, mediate TLR7-induced TAK1-dependent NFκB activation. IRAK-M was previously known to fu...
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| Autors principals: | , , , , , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
European Molecular Biology Organization
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3579143/ https://ncbi.nlm.nih.gov/pubmed/23376919 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.2 |
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