IRAK-M mediates Toll-like receptor/IL-1R-induced NFκB activation and cytokine production

Toll-like receptors transduce their signals through the adaptor molecule MyD88 and members of the IL-1R-associated kinase family (IRAK-1, 2, M and 4). IRAK-1 and IRAK-2, known to form Myddosomes with MyD88–IRAK-4, mediate TLR7-induced TAK1-dependent NFκB activation. IRAK-M was previously known to fu...

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Hauptverfasser: Zhou, Hao, Yu, Minjia, Fukuda, Koichi, Im, Jinteak, Yao, Peng, Cui, Wei, Bulek, Katarzyna, Zepp, Jarod, Wan, Youzhong, Whan Kim, Tae, Yin, Weiguo, Ma, Victoria, Thomas, James, Gu, Jun, Wang, Jian-an, DiCorleto, Paul E, Fox, Paul L, Qin, Jun, Li, Xiaoxia
Format: Artigo
Sprache:Inglês
Veröffentlicht: European Molecular Biology Organization 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3579143/
https://ncbi.nlm.nih.gov/pubmed/23376919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.2
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