SOX2 Co-Occupies Distal Enhancer Elements with Distinct POU Factors in ESCs and NPCs to Specify Cell State

SOX2 is a master regulator of both pluripotent embryonic stem cells (ESCs) and multipotent neural progenitor cells (NPCs); however, we currently lack a detailed understanding of how SOX2 controls these distinct stem cell populations. Here we show by genome-wide analysis that, while SOX2 bound to a d...

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Autors principals: Lodato, Michael A., Ng, Christopher W., Wamstad, Joseph A., Cheng, Albert W., Thai, Kevin K., Fraenkel, Ernest, Jaenisch, Rudolf, Boyer, Laurie A.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3578749/
https://ncbi.nlm.nih.gov/pubmed/23437007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003288
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