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The Insulin Receptor: Both a Prototypical and Atypical Receptor Tyrosine Kinase
Unlike prototypical receptor tyrosine kinases (RTKs), which are single-chain polypeptides, the insulin receptor (InsR) is a preformed, covalently linked tetramer with two extracellular α subunits and two membrane-spanning, tyrosine kinase-containing β subunits. A single molecule of insulin binds asy...
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| Formato: | Artigo |
| Idioma: | Inglês |
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Cold Spring Harbor Laboratory Press
2013
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3578362/ https://ncbi.nlm.nih.gov/pubmed/23457259 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a008946 |
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