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Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog.
The crystal structure of the phosphorylated, activated form of the insulin receptor tyrosine kinase in complex with a peptide substrate and an ATP analog has been determined at 1.9 A resolution. The activation loop (A-loop) of the kinase undergoes a major conformational change upon autophosphorylati...
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| Autor principal: | |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1997
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1170189/ https://ncbi.nlm.nih.gov/pubmed/9312016 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.18.5572 |
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