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Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog.

The crystal structure of the phosphorylated, activated form of the insulin receptor tyrosine kinase in complex with a peptide substrate and an ATP analog has been determined at 1.9 A resolution. The activation loop (A-loop) of the kinase undergoes a major conformational change upon autophosphorylati...

詳細記述

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書誌詳細
第一著者: Hubbard, S R
フォーマット: Artigo
言語:Inglês
出版事項: 1997
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170189/
https://ncbi.nlm.nih.gov/pubmed/9312016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.18.5572
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