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Kinetic analysis and evaluation of the mechanisms involved in the resolution of experimental nontypeable Haemophilus influenzae-induced otitis media after transcutaneous immunization

Transcutaneous immunization (TCI) is a simple and needle-free method with which to induce protective immune responses. Using a chinchilla model of nontypeable Haemophilus influenzae (NTHI)-induced otitis media (OM), we examined the efficacy afforded by TCI with a novel chimeric immunogen called ‘chi...

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Autori principali: Novotny, Laura A., Clements, John D., Bakaletz, Lauren O.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3578125/
https://ncbi.nlm.nih.gov/pubmed/23092856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2012.10.033
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