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Rheumatoid Factor B Cell Memory Leads to Rapid, Switched Antibody Forming Cell Responses

B cells are critical in the initiation and maintenance of lupus. Autoreactive B cells clonally expand, isotype switch and mutate—properties associated with memory B cells (MBC), which are typically generated via germinal centers (GCs). The development and functions of autoreactive MBC in lupus are p...

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Библиографические подробности
Главные авторы: Sweet, Rebecca A., Cullen, Jaime L., Shlomchik, Mark J.
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3578004/
https://ncbi.nlm.nih.gov/pubmed/23365079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1202816
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