Distinct T cell receptor signaling pathways drive proliferation and cytokine production in T cells

The physiological basis and mechanistic requirement for the high immunoreceptor tyrosine activation motifs (ITAM) multiplicity of the T cell receptor (TCR)-CD3 complex remains obscure. Here we show that while low TCR-CD3 ITAM multiplicity is sufficient to engage canonical TCR-induced signaling event...

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Detalhes bibliográficos
Main Authors: Guy, Clifford S., Vignali, Kate M., Temirov, Jamshid, Bettini, Matthew, Overacre, Abigail E., Smeltzer, Matthew, Zhang, Hui, Huppa, Johannes B., Tsai, Yu-Hwai, Lobry, Camille, Xie, Jianming, Dempsey, Peter J., Crawford, Howard C., Aifantis, Iannis, Davis, Mark M., Vignali, Dario A.A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3577985/
https://ncbi.nlm.nih.gov/pubmed/23377202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2538
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