Imatinib Ameliorates Neuroinflammation in a Rat Model of Multiple Sclerosis by Enhancing Blood-Brain Barrier Integrity and by Modulating the Peripheral Immune Response

Central nervous system (CNS) disorders such as ischemic stroke, multiple sclerosis (MS) or Alzheimeŕs disease are characterized by the loss of blood-brain barrier (BBB) integrity. Here we demonstrate that the small tyrosine kinase inhibitor imatinib enhances BBB integrity in experimental autoimmune...

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Hlavní autoři: Z. Adzemovic, Milena, Zeitelhofer, Manuel, Eriksson, Ulf, Olsson, Tomas, Nilsson, Ingrid
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3577871/
https://ncbi.nlm.nih.gov/pubmed/23437178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0056586
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