Imatinib Ameliorates Neuroinflammation in a Rat Model of Multiple Sclerosis by Enhancing Blood-Brain Barrier Integrity and by Modulating the Peripheral Immune Response

Central nervous system (CNS) disorders such as ischemic stroke, multiple sclerosis (MS) or Alzheimeŕs disease are characterized by the loss of blood-brain barrier (BBB) integrity. Here we demonstrate that the small tyrosine kinase inhibitor imatinib enhances BBB integrity in experimental autoimmune...

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Bibliografische gegevens
Hoofdauteurs: Z. Adzemovic, Milena, Zeitelhofer, Manuel, Eriksson, Ulf, Olsson, Tomas, Nilsson, Ingrid
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2013
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3577871/
https://ncbi.nlm.nih.gov/pubmed/23437178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0056586
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