N-terminal phosphorylation of cardiac troponin-I reduces length-dependent calcium sensitivity of contraction in cardiac muscle

Protein kinase A (PKA) phosphorylation of myofibrillar proteins constitutes an important pathway for β-adrenergic modulation of cardiac contractility. In myofilaments PKA targets troponin I (cTnI), myosin binding protein-C (cMyBP-C) and titin. We studied how this affects the sarcomere length (SL) de...

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Detalhes bibliográficos
Main Authors: Rao, Vijay S, Korte, F Steven, Razumova, Maria V, Feest, Erik R, Hsu, Hsiaoman, Irving, Thomas C, Regnier, Michael, Martyn, Donald A
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2013
Assuntos:
Cardiovascular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3577517/
https://ncbi.nlm.nih.gov/pubmed/23129792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2012.241604
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