Channel-mediated astrocytic glutamate release via Bestrophin-1 targets synaptic NMDARs

BACKGROUND: Astrocytes regulate neuronal excitability and synaptic activity by releasing gliotransmitters such as glutamate. Our recent study demonstrated that astrocytes release glutamate upon GPCR activation via Ca(2+) activated anion channel, Bestrophin-1 (Best1). The target of Best1-mediated ast...

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Main Authors: Han, Kyung-Seok, Woo, Junsung, Park, Hyungju, Yoon, Bong-June, Choi, Sukwoo, Lee, C Justin
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2013
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3577500/
https://ncbi.nlm.nih.gov/pubmed/23324492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-6606-6-4
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